Effect of Electroacupuncture on Monoamine Neurotransmitters in Brain Tissue of Young Rats with Cerebral Palsy

Liu Zhenhuan¹Pan Pei Guang¹Zhao Yong¹Qi Yanchao²

1.Nanhai Obstetrics and Gynecology and Children's Hospital Affiliated to Guangzhou University of Chinese Medicine2.Guangzhou Cancer Hospital

Abstract: Objective: To detect the content of monoamine neurotransmitters in hippocampus, cortex, basal nucleus and brainstem of cerebral palsy rats, observe the effect of acupuncture on them, and explore the mechanism of acupuncture in the treatment of cerebral palsy rats. Methods: The model of cerebral palsy was prepared by the method of ischemia and hypoxia, the brain was decapitated after acupuncture treatment, the required brain areas were separated, and the content of monoamine neurotransmitters was detected by spectrophotometer. Results: Compared with the sham operation group, the contents of dopamine (DA) and 5-hydroxytryptamine (5-HT) in the basal nucleus and norepinephrine (NE) in the brainstem of cerebral palsy rats were significantly decreased (P<0.05), and the contents of dopamine (DA) and 5-hydroxytryptamine (5-HT) in the basal nucleus and norepinephrine (NE) in the brainstem of cerebral palsy rats were significantly increased after acupuncture treatment (P<0.05). Conclusion: It is suggested that increasing the content of monoamine neurotransmitters in the relevant brain regions may be one of the possible mechanisms of acupuncture in the treatment of cerebral palsy in young rats.

Key words:Monoamine neurotransmitters;Acupuncture treatment;

The Third National Children's Rehabilitation Academic Conference The Tenth National Symposium on Pediatric Cerebral Palsy

Meeting time: 2008-05

Venue: Guangzhou, Guangdong, China

• Album: Medical and Health Technology
• Topic: Traditional Chinese Medicine
• Classification number: R245

Effect of Electroacupuncture on Monoamine Neurotransmitters in Brain Tissue of Cerebral Palsy Rats