Relationship between polymorphism in 3 ′ untranslated region of HSPA5 gene and prognosis of hepatocellular carcinoma

Pan Dongxiao^1,2Shen Hongzhuo^1,2Wang Jinlong^1,2Ye Weicheng^1,2Hu Shuzhen^1,2Qi Yanchao^1,2Zhu Xiao^1,2

1. Cancer Institute, Affiliated Cancer Hospital of Guangzhou Medical College2. Department of Clinical Laboratory, Affiliated Tumor Hospital of Guangzhou Medical College

Abstract:Objective To investigate the relationship between the variation in the 3 ′ untranslated region of the 70 kDa heat shock protein 5(HSPA5) gene and the prognosis of hepatocellular carcinoma (HCC). Methods DNA was extracted from the peripheral blood of 288 patients with hepatocellular carcinoma, and the rs16927997, rs1140763 and rs12009 of HSPA5 gene were detected by TaqMan. Kaplan-Meier methods and Log-rank test were used to evaluate overall survival. Results The distribution of HSPA5 haplotypes did not correlate with clinical characteristics. Univariate analysis showed that allele, genotype, haplotype, and diplotype did not affect survival. Multiple comparisons showed that clinical features were not associated with overall patient outcomes (P>0.05). Conclusion The variation in the 3 ′ untranslated region of HSPA5 gene in Chinese has no significant effect on the prognosis of HCC.

Key words:hot body protein 5;Hepatocellular carcinoma;Polymorphism;prognosis;

Funding:National Natural Science Foundation of China (81071697); Guangzhou Education Bureau Fund (10A192); Guangzhou Health Bureau Fund (201102A213005);

Album:Medical and Health Science and Technology

Topic:Oncology

Classification number:R735.7

Relationship between polymorphism of HSPA5 gene 3 'untranslated region and prognosis of hepatocellular carcinoma