Enhancing effect of Anjifu injection on experimental immunosuppression in mice

Mingliang, Li Jinpei, Li Weiping, Zhang Yan, Qi Yanchao

1. Department of Pharmacology, Anhui Medical University2. Henan Cancer Research Institute

Abstract: Objective: To study the effect of Anjifu injection on experimental immunosuppression in mice. Methods: The animal model of immunocompromised caused by cyclophosphamide (Cy80mg-kg-1SC) was used to determine the relevant immune indicators by carbon particle clearance, one-way immunodiffusion, dinitrofluorobenzene-induced delayed-type hypersensitivity, 3H-TdR participation and indirect immunofluorescence. Results: Anji Fu Injection (0.01, 0.1mg kg-1 d-1 × 10d,im) can significantly increase the reduced K value, α value, serum IgG, ear swelling degree and ConA-induced T lymphocyte proliferation response value in mice. At the same time, it can increase the decreased L3T4 + cells in peripheral blood of mice, thus increasing the decreased L3T4 +/Lyt-2 + cell ratio. Conclusion: Anjifu injection has a significant enhancement effect on experimental immunosuppression in mice.

Key words:Anjifu injection; cyclophosphamide; immunomodulatory effect; T lymphocyte subsets; mice;

• Album: Medical and Health Technology
• Topic: Pharmacy
• Classification number: R979.5

Enhancement of Anji Fu Injection on Experimental Immune Function in Mice_Mingliang. pdf