Effect of Electroacupuncture on Monoamine Neurotransmitters in Brain Tissue of Young Rats with Cerebral Palsy

Liu Zhenhuan¹Pan Pei Guang¹Zhao Yong¹Qi Yanchao²

1.Nanhai Obstetrics and Gynecology and Children's Hospital Affiliated to Guangzhou University of Chinese Medicine2.Guangzhou Cancer Hospital

Abstract:Objective: To detect the contents of monoamine neurotransmitters in hippocampus, cortex, basal nucleus and brainstem tissues of young rats with cerebral palsy, to observe the effect of acupuncture on them, and to explore the mechanism of acupuncture in the treatment of young rats with cerebral palsy. Methods: The model of cerebral palsy was prepared by the method of ischemia and hypoxia, the brain was decapitated after acupuncture treatment, the required brain areas were separated, and the content of monoamine neurotransmitters was detected by spectrophotometer. Results: Compared with the sham operation group, the contents of dopamine (DA) and 5-hydroxytryptamine (5-HT) in the basal nucleus and norepinephrine (NE) in the brainstem of cerebral palsy rats were significantly decreased (P<0.05), and the contents of dopamine (DA) and 5-hydroxytryptamine (5-HT) in the basal nucleus and norepinephrine (NE) in the brainstem of cerebral palsy rats were significantly increased after acupuncture treatment (P<0.05). Conclusion: It is suggested that increasing the content of monoamine neurotransmitters in the relevant brain regions may be one of the possible mechanisms of acupuncture in the treatment of cerebral palsy in young rats.

Key words:Acupuncture;Cerebral palsy;Monoamine neurotransmitters;

Conference Name:The 16th National Acupuncture and Moxibustion Clinical Symposium, the 11th National Auricular Acupoint Diagnosis and Treatment Symposium, Contemporary Clinical Treatment Forum and Academic Symposium of Ten Central and Western Provinces

Meeting time:2008-08

Venue:China Guizhou Guiyang

Album:Medical and Health Science and Technology

Topic:Traditional Chinese Medicine

Classification number:R245

Effect of electroacupuncture on monoamine neurotransmitters in brain tissue of cerebral palsy rats