Sage effect of mesenchymal stem cells in the treatment of refractory lupus erythematosus

Systemic lupus erythematosus is an autoimmune disease, the cause of which is not clear. It is currently considered to be related to genetic, viral infection, sex hormones, ultraviolet rays, drugs and other factors. In the early stage, only a single organ is involved, with irregular low fever. In the acute active stage, there may be high fever, enlarged lymph nodes, butterfly erythema on facial skin, painless ulcers on oral and nasal mucosa, and muscle and joint pain. Later extended to multi-system damage. Clinically, there are hematuria, proteinuria, myocarditis, lupus nephritis, abdominal spastic pain, decreased liver function, epileptic seizures and organic encephalopathy, irritable, obsessive-compulsive, hallucinations and other mental symptoms, general fatigue, weight loss and so on. In order to allow patients to better cooperate with the treatment, so that the disease in the early stages of remission and stability, do not develop to multiple organ damage.

Due to facial, acral erythema, mouth and nose ulcers, alopecia, long-term use of hormones to change the appearance, the patient's ideological burden is heavy, the spirit is extremely painful, should be more concerned and considerate; The disease is easy to relapse, let the patient understand the need for long-term recuperation, lasting treatment, eliminate or reduce their sorrow, anxiety, with typical examples to encourage patients to establish confidence in overcoming the disease.
In the course of treatment, we often use the following methods:

1. Hormone is currently the main drug for the treatment of systemic lupus erythematosus, long-term use of dependence, side effects are obvious

2. Immunosuppressive agents, side effects are obvious, during the application of such drugs should drink more water, and regular review of blood and renal function.

3. symptomatic treatment, did not fundamentally improve the disease.

4. Stem cell therapy, after treatment, the serum creatinine, blood urea nitrogen, blood albumin, serum complement C3 and autoimmune antibodies in refractory SLE subjects have a certain degree of improvement, no obvious side effects, the effect is good.

Professor Qi Yanchao has been engaged in stem cell research for many years and has achieved satisfactory results for several patients with lupus erythematosus. The following is an example of treatment.
● Time: 2005
● Location: Guangzhou
● Patient: Cai Linrong, male, 14 years old
● The situation of Professor Qi's former Cai:

Suffering from systemic lupus erythematosus, lupus brain, lupus nephritis with bilateral pleural effusion, systemic edema, cough, sputum, vomiting and other 5 years. After multiple treatment, the effect is not good. Moreover, anemia is serious and depends on blood transfusion once a week to maintain life. Some doctors have also lost confidence and advised their families to give up treatment.

In despair, holding a glimmer of hope, try biological treatment. On October 8, 2005, biological treatment was added. After a course of treatment, the condition improved significantly, cough, expectoration, vomiting symptoms improved significantly. Edema disappeared, bilateral pleural effusion disappeared.

Results of laboratory examination before and after treatment with Cai Linrong

After two courses of laboratory examination, in addition to proteinuria biological treatment before and after no significant change, other indicators returned to normal

When Cai Linrong was young, he felt inferior in front of his classmates due to illness. It was difficult to see his smiling face. Due to the good treatment effect, the children are now much more cheerful. At that time, his family arranged for him to start school and study.

After half a year of treatment, Cai Linrong grew up (May 18, 2006)

In the future, every six months, Cai Linrong will come to Guangzhou for treatment. His health is getting better and better. His life at school has also changed his personality,
Sometimes when I come, I will talk to Professor Qi about life and work. Now I have more hope for life.

Five years later (28 May 2010)