Study on the effect of Fuzhengpei method on dendritic cells in patients with breast cancer

Li Hongsheng¹Fang Chihua¹Wang Yuandong²Su Xuchun²Yang Bo²Qi Yanchao²Liu Chenglin²Lu Minying²

1. Department of General Surgery, Zhujiang Hospital, Southern Medical University 2. Department of Integrated Traditional Chinese and Western Medicine, Department of Thoracic Surgery, Cancer Hospital, Guangzhou Medical College

Abstract: Objective: To explore the repair effect and mechanism of the damage of the immune function of the body from the cell and molecular level. Methods: The expression levels of CD83, CD80 and CD86 proteins in cancer tissues and draining lymph nodes of patients with breast cancer were detected by flow cytometry and the changes before and after chemotherapy. Results: The levels of CD83, CD80 and CD86 in cancer tissues and axillary lymph node cells in breast cancer patients were significantly lower than those in benign controls (P<0.05 or 0.01), and the levels of CD83, CD80 and CD86 in cancer tissues and axillary lymph node cells before and after chemotherapy were significantly lower than those in benign controls (P<0.05 or 0.01). There was no significant difference in the levels of CD83, CD80 and CD86 in cancer tissues and axillary lymph node cells before and after chemotherapy (P>0.05). Conclusion: The tumor itself and chemotherapy have adverse effects on the immune function of the body. Fuzhengpei's method may be involved in activating the function of dendritic cells, up-regulating the level of costimulatory molecules, and helping to repair the body's immune damage.

Key words:breast cancer;Neoadjuvant chemotherapy;Cellular immune function;Fuzheng Peiben;

Funding:Project Supported by Integrated Traditional Chinese and Western Medicine Fund of Guangdong Provincial Bureau of Traditional Chinese Medicine (Project No.: 1050068); Project supported by the Traditional Chinese Medicine and Integrated Traditional Chinese and Western Medicine Fund of Guangzhou Municipal Health Bureau (Project No.: 2005A038);

• Change: 10.13863/j. isdn1001-4454. 2007.03.046
• Album: Medical and Health Technology
• Topic: Traditional Chinese Medicine
• Classification number: R273

Study on the Effect of Fuzhengpei's Method on Dendritic Cells in Breast Cancer Patients_Li Hongsheng. pdf