Observation and nursing of cord blood CD3AK cells in the treatment of malignant tumor

Zhang GuihuaPan DongxiaoQi ZhonghaoShi QiangQi Yanchao

Clinical Oncology Research Center of Guangzhou Medical College and Guangzhou Cancer Hospital

Abstract: Objective To study the anti-tumor effect of CD3AK cells prepared from umbilical cord blood mononuclear cells, and to explore the immune indicators of the short-term efficacy of tumor biotherapy and the nursing standards in clinical application. Methods Cord blood mononuclear cells were isolated, and CD3AK cells were induced by IL-2 + CD3Ab. The natural killer (NK) activity of peripheral blood mononuclear cells (PBMC) in tumor patients was measured before and after treatment with CD3AK cells. Results After a course of infusion of CD3AK cells in tumor patients, the NK killing activity of PBMC increased from 63% to 81%, with an average increase of 28%. The febrile reaction was less than 3%, mostly below 38 ℃, and subsided spontaneously without treatment. Conclusion (1)CD3AK cell infusion can significantly improve the NK activity of PBMC in tumor patients;(2)CD3AK cell infusion is safe and effective, with no obvious side effects;(3) NK activity measurement of PBMC in tumor patients is expected to become a parameter of the short-term efficacy of tumor biotherapy.

Key words:Cord blood;CD3AK cell infusion;Observation;nursing;

Funding:Key Scientific and Technological Tackling Projects of Guangzhou Science and Technology Bureau (No. JB0299-Z-102-09);

• Album: Medical and Health Technology
• Topic: Clinical Medicine
• Classification number: R473.73

Observation and Nursing of Cord Blood CD_3AK Cells in the Treatment of Malignant Tumors_Zhang Guihua.pdf